Structural and Molecular Nanobiotechnology of DNA Repair Processes
Cancer related
(Synergic R&D Projects. Reference: Y2018 / BIO-4747)
NanoBioCancer forms the core of an ambitious program to study DNA repair and his relationship with cancer, from structural analysis by high-resolution electron cryomicroscopy and cutting-edge single-molecule technology.
The project NanoBioCancer combine the molecular biophysics and the structural biology to decipher the mechanisms of DNA repair processes and their relationship with cancer. NanoBioCancer gathers from leading groups, internationally recognized, in electron microscopy and in single molecule techniques , two techniques that are revolutionizing cutting-edge biomedical research.
goals
1. Development of new methods of structural and molecular nanobiotechnology.
PlusDevelop new methods for purification of native complexes and advance available single molecule technology, incorporating imaging techniques with TIRF and AFM microscopy.
2. Structural and molecular nanobiotechnology of DNA repair.
PlusDefects in DNA damage repair systems are responsible for tumor development. Thus, proteins involved in DNA repair are good candidates for the development of new therapies. One of the main repair systems is that of “non-homologous end junction (NHEJ)”, of which a third component has recently been discovered: LINP1, that appears overexpressed in triple negative breast cancers. This objective aims to provide a comprehensive vision (structural, molecular and dynamic) the role of LINP1 in the NHEJ repair system.
3. Structural and molecular nanobiotechnology of telomere replication.
PlusSummary web page: Telomeres are structures that protect the ends of chromosomes and aid their replication. Telomeres shorten with each DNA replication, telomerase is an enzyme that specializes in the replication and maintenance of these structures, but it requires the participation of other proteins to carry out its mission. Our goal is to use techniques of manipulation of individual molecules and structural characterization to understand the mechanisms of telomere maintenance and define the structures of the proteins involved..
4. Search for new molecules with potential therapeutic interest in cancer.
PlusSummary web page: The objective is to focus on the search for small molecules that act as inhibitors of the activity of proteins involved in the response to DNA damage and to telomere replication.. The idea is that these molecules are the starting point for the generation of new therapeutic strategies against cancer..
5. Elaboration of a competitive proposal ERC Synergy.
PlusAfter carrying out an analysis of previous successful proposals and looking for new partners related to the field, we will prepare a competitive ERC-Synergy proposal.
Participating groups
FMH-CNB (Molecular biophysics)
Coordinator and group leader
Fernando Moreno-Herrero
Members
Clara Aicart Ramos
Silvia Hormeño Torres
Francisco Balaguer Pérez
Mikel Marín Baquero
Sara de Bragança Vieira
Ania Dobieżyńska
Karolina Gmurzczyk
Eva Martin Cuevas
Ana García del Arco
Maria Teresa Arranz Sarmiento
know us
OLI-CNIO (Macromolecular Complexes in DNA Damage Response Group
Group leader
Oscar A. Llorca Blanco
Members
Javier Coloma Cervera
Andrés López Perrote
Ángel Rivera Calzada
Javier Coloma Cervera
Marina Serna Gil
Adrian del Rincón Beneytez
Carlos Fernández Rodríguez
María Ibarra Dauden
Alba Ruiz Ramos
Nayim González Rodríguez
know us
News and events
Molecular architecture and oligomerization of Candida glabrata Cdc13 underpin its telomeric DNA-binding and unfolding activity
Take a look at the new publication resulting from the collaboration of the groups of Oscar Llorca and Fernando Moreno-Herrero, next to Neal F Lue's lab (Weill Cornell Medical College).
APLF and long non-coding RNA NIHCOLE promote stable DNA synapsis in non-homologous end joining
Do not miss the following publication that has been the result of the effort and cohesion of 2 Tec4Bio consortium groups together with CIMA researchers (university of Navarra). Congratulations to all involved for the work!
Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus
Pay attention to the new publication of the Oscar Llorca group in collaboration with the laboratory of Laurence H. Pearl (University of Sussex/Institute of Cancer Research).
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Publications
- Publications
- Thesis
Recent posts
Thesis
Doctoral student: Alberto Marín-González
Group: FMH-CNB (Molecular biophysics)
Title: “Combining Molecular Dynamics Simulations and Atomic Force Microscopy Experiments to Rationalize the Mechanical Properties of Double-Stranded DNA and RNA”
Date: 06/03/2020
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Collaborating Groups
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DNA Interactions Research Group:protein interaction(Mark S. Dillingham, Bristol University)
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Research Group on non-coding RNAs in hepatocarcinoma and other liver diseases (Dr. Puri Fortes, CIMA)
Affiliates
Services and Infrastructures
Job vacancies
Market Stall
Location
Group
Date
Carlos III National Cancer Research Center, CNIO (Madrid)
Dr. Oscar Llorca (OVER-CNIO)
12/03/2021
CNB-CSIC (Madrid, Campus Cantoblanco)
Dr. Fernando Moreno-Herrero (FMH-CNB)
08/01/2020
CNB-CSIC (Madrid, Campus Cantoblanco)
Dr. Fernando Moreno-Herrero (FMH-CNB)
19/10/2019